Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment

Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment

The repair of focal articular cartilage defects remains a problem. Combining gene therapy with tissue engineering approaches using bone marrow-derived mesenchymal stem cells (MSCs) may allow the development of improved options for cartilage repair. Here, we examined whether a three-dimensional fibri...

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Bibliographic Details
Main Authors: Jagadeesh K. Venkatesan, Oliver Gardner, Ana Rey-Rico, David Eglin, Mauro Alini, Martin J. Stoddart, Magali Cucchiarini, Henning Madry
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
cartilage repair
hMSCs
chondrogenesis
rAAV
SOX9
fibrin-polyurethane scaffolds
bioreactors
Online Access:http://www.mdpi.com/1422-0067/19/9/2635

Internet

http://www.mdpi.com/1422-0067/19/9/2635

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