MiR-145 negatively regulates TGFBR2 signaling responsible for sepsis-induced acute lung injury

MiR-145 negatively regulates TGFBR2 signaling responsible for sepsis-induced acute lung injury

This study aims to explore the roles of miR-145/TGFBR2 axis in sepsis-induced acute lung injury. Here, RNA-sequencing assay showed that miR-145 was significantly decreased in exosomes from sepsis patient blood samples. And miR-145 was decreased but TGFBR2 was increased in LPS-treated mice lung tissu...

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Bibliographic Details
Main Authors: Xiaohua Cao, Chenchen Zhang, Xiuli Zhang, Yu Chen, Hui Zhang
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sepsis
Lung injury
MiR-145
TGFBR2
LPS
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218379381

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http://www.sciencedirect.com/science/article/pii/S0753332218379381

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