A novel target enrichment strategy in next-generation sequencing through 7-deaza-dGTP-resistant enzymatic digestion

A novel target enrichment strategy in next-generation sequencing through 7-deaza-dGTP-resistant enzymatic digestion

Abstract Objective Owing to the overwhelming dominance of human and commensal microbe sequences, low efficiency is a major concern in clinical viral sequencing using next-generation sequencing. DNA composed of 7-deaza-2′-deoxyguanosine 5′-triphosphate (c7dGTP), an analog of deoxyguanosine triphospha...

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Bibliographic Details
Main Authors: Peng Peng, Yanjuan Xu, Adrian M. Di Bisceglie, Xiaofeng Fan
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Research Notes
Subjects:
Next-generation sequencing
Target enrichment
7-deaza-2′-deoxyguanosine 5′-triphosphate
Hepatitis B virus
Online Access:http://link.springer.com/article/10.1186/s13104-020-05292-y

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http://link.springer.com/article/10.1186/s13104-020-05292-y

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