HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway

HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway

Summary: Here, we show that HEMATOLOGICAL AND NEUROLOGICAL EXPRESSED 1-LIKE (HN1L) is a targetable breast cancer stem cell (BCSC) gene that is altered in 25% of whole breast cancer and significantly correlated with shorter overall or relapse-free survival in triple-negative breast cancer (TNBC) pati...

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Bibliographic Details
Main Authors: Yi Liu, Dong Soon Choi, Jianting Sheng, Joe E. Ensor, Diana Hwang Liang, Cristian Rodriguez-Aguayo, Amanda Polley, Steve Benz, Olivier Elemento, Akanksha Verma, Yang Cong, Helen Wong, Wei Qian, Zheng Li, Sergio Granados-Principal, Gabriel Lopez-Berestein, Melissa D. Landis, Roberto R. Rosato, Bhuvanesh Dave, Stephen Wong, Dario Marchetti, Anil K. Sood, Jenny C. Chang
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Stem Cell Reports
Subjects:
HN1L
LEPR
STAT3
TNBC
cancer stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117305179

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http://www.sciencedirect.com/science/article/pii/S2213671117305179

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