Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines.

Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines.

Factor H binding protein (fHbp) is a major protective antigen in 4C-MenB (Bexsero®) and Trumenba®, two serogroup B meningococcal vaccines, wherein expression level is a determinant of protection. Examination of promoter-containing intergenic region (IGR) sequences indicated that nine fHbp IGR allele...

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Bibliographic Details
Main Authors: Caroline Cayrou, Ayodeji A Akinduko, Evgeny M Mirkes, Jay Lucidarme, Stephen A Clark, Luke R Green, Helen J Cooper, Julie Morrissey, Ray Borrow, Christopher D Bayliss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0197186

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https://doi.org/10.1371/journal.pone.0197186

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