TROUBLE SHOOTING DURING BIOANALYTICAL ESTIMATION OF DRUG AND METABOLITES USING LC-MS/MS: A REVIEW

Bioanalysis frequently involves the measurement of very low analyteconcentrations in complex and potentially variable matrices. An initial attempt has beenmade to apply a risk management tool to the bioanalytical method development likeselection of spiked plasma volume, selection of internal standar...

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Bibliographic Details
Main Authors: K.K.Sharma, Man Mohan Singhal, Ganesh N. Sharma, Jyotsana Sanadya
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2010-03-01
Series:Journal of Advanced Pharmaceutical Technology & Research
Subjects:
Online Access:http://122.168.195.169/Online%20Admission/CourseInstr.aspx?STS=4&MID=37&Title=Trouble%20Shooting%20During%20Bioanalytical%20Estimation%20Of%20Drug%20And%20Metabolites%20Using%20LC-MS/MS:%20A%20Review