Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a...
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2018-12-01
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Online Access: | https://doi.org/10.1038/s41467-018-06256-4 |
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doaj-6ac458ba736146368698999f73b606662021-05-11T09:26:33ZengNature Publishing GroupNature Communications2041-17232018-12-01911910.1038/s41467-018-06256-4Honey bee Royalactin unlocks conserved pluripotency pathway in mammalsDerrick C. Wan0Stefanie L. Morgan1Andrew L. Spencley2Natasha Mariano3Erin Y. Chang4Gautam Shankar5Yunhai Luo6Ted H. Li7Dana Huh8Star K. Huynh9Jasmine M. Garcia10Cole M. Dovey11Jennifer Lumb12Ling Liu13Katharine V. Brown14Abel Bermudez15Richard Luong16Hong Zeng17Victoria L. Mascetti18Sharon J. Pitteri19Jordon Wang20Hua Tu21Marco Quarta22Vittorio Sebastiano23Roel Nusse24Thomas A. Rando25Jan E. Carette26J. Fernando Bazan27Kevin C. Wang28Department of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineDepartment of Microbiology and Immunology, Stanford University School of MedicineDepartment of Microbiology and Immunology, Stanford University School of MedicineThe Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Developmental Biology, Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineCanary Center for Cancer Early Detection, Department of Radiology, Stanford University School of MedicineDepartment of Comparative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineCanary Center for Cancer Early Detection, Department of Radiology, Stanford University School of MedicineLakePharma, Inc.LakePharma, Inc.The Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of MedicineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineDepartment of Developmental Biology, Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineThe Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of MedicineDepartment of Microbiology and Immunology, Stanford University School of MedicineR&D Systems, IncDepartment of Dermatology, Program in Epithelial Biology, Stanford University School of MedicineRoyal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a ground-state pluripotency-like gene network.https://doi.org/10.1038/s41467-018-06256-4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Derrick C. Wan Stefanie L. Morgan Andrew L. Spencley Natasha Mariano Erin Y. Chang Gautam Shankar Yunhai Luo Ted H. Li Dana Huh Star K. Huynh Jasmine M. Garcia Cole M. Dovey Jennifer Lumb Ling Liu Katharine V. Brown Abel Bermudez Richard Luong Hong Zeng Victoria L. Mascetti Sharon J. Pitteri Jordon Wang Hua Tu Marco Quarta Vittorio Sebastiano Roel Nusse Thomas A. Rando Jan E. Carette J. Fernando Bazan Kevin C. Wang |
spellingShingle |
Derrick C. Wan Stefanie L. Morgan Andrew L. Spencley Natasha Mariano Erin Y. Chang Gautam Shankar Yunhai Luo Ted H. Li Dana Huh Star K. Huynh Jasmine M. Garcia Cole M. Dovey Jennifer Lumb Ling Liu Katharine V. Brown Abel Bermudez Richard Luong Hong Zeng Victoria L. Mascetti Sharon J. Pitteri Jordon Wang Hua Tu Marco Quarta Vittorio Sebastiano Roel Nusse Thomas A. Rando Jan E. Carette J. Fernando Bazan Kevin C. Wang Honey bee Royalactin unlocks conserved pluripotency pathway in mammals Nature Communications |
author_facet |
Derrick C. Wan Stefanie L. Morgan Andrew L. Spencley Natasha Mariano Erin Y. Chang Gautam Shankar Yunhai Luo Ted H. Li Dana Huh Star K. Huynh Jasmine M. Garcia Cole M. Dovey Jennifer Lumb Ling Liu Katharine V. Brown Abel Bermudez Richard Luong Hong Zeng Victoria L. Mascetti Sharon J. Pitteri Jordon Wang Hua Tu Marco Quarta Vittorio Sebastiano Roel Nusse Thomas A. Rando Jan E. Carette J. Fernando Bazan Kevin C. Wang |
author_sort |
Derrick C. Wan |
title |
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals |
title_short |
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals |
title_full |
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals |
title_fullStr |
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals |
title_full_unstemmed |
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals |
title_sort |
honey bee royalactin unlocks conserved pluripotency pathway in mammals |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-12-01 |
description |
Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a ground-state pluripotency-like gene network. |
url |
https://doi.org/10.1038/s41467-018-06256-4 |
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