Ionic Mechanisms of Disopyramide Prolonging Action Potential Duration in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

Ionic Mechanisms of Disopyramide Prolonging Action Potential Duration in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

Short QT syndrome (SQTS) is associated with tachyarrhythmias and sudden cardiac death. So far, only quinidine has been demonstrated to be effective in patients with SQTS type 1(SQTS1). The aim of this study was to investigate the mechanisms of disopyramide underlying its antiarrhythmic effects in SQ...

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Bibliographic Details
Main Authors: Huan Lan, Qiang Xu, Ibrahim El-Battrawy, Rujia Zhong, Xin Li, Siegfried Lang, Lukas Cyganek, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
short QT syndrome
arrhythmias
antiarrhythmic drugs
disopyramide
human-induced pluripotent stem cell-derived cardiomyocytes
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.554422/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.554422/full

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