Paths of heritable mitochondrial DNA mutation and heteroplasmy in reference and gas-1 strains of Caenorhabditis elegans

Paths of heritable mitochondrial DNA mutation and heteroplasmy in reference and gas-1 strains of Caenorhabditis elegans

Heteroplasmy—the presence of more than one mitochondrial DNA (mtDNA) sequence type in a cell, tissue, or individual—impacts human mitochondrial disease and numerous aging-related syndromes. Understanding the trans-generational dynamics of mtDNA is critical to understanding the underlying mechanisms...

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Bibliographic Details
Main Authors: Riana eWernick, Dana eHowe, Suzanne eEstes, Dee eDenver
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Genetics
Subjects:
Caenorhabditis elegans
Mutation
experimental evolution
mitochondrial DNA
Heteroplasmy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00051/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00051/full

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