Glucose kinetics in the collagen-induced arthritis model: an all-in-one model to assess both efficacy and metabolic side effects of glucocorticoids.

Glucose kinetics in the collagen-induced arthritis model: an all-in-one model to assess both efficacy and metabolic side effects of glucocorticoids.

Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory drugs, but chronic use is hampered by metabolic side effects. Therefore, there is an urgent medical need for improved GCs that are as effective as classical GCs but have a better safety profile. A well-established model to ass...

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Bibliographic Details
Main Authors: Erik J M Toonen, Anke J Laskewitz, Theo H van Dijk, Aycha Bleeker, Aldo Grefhorst, Annelies E Schouten, Ellen A J Bastiaanssen, Dov B Ballak, Marije I Koenders, Cindy van Doorn, Monique A J van der Vleuten, Marie-Jose C van Lierop, Albert K Groen, Wim H A Dokter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4151983?pdf=render

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http://europepmc.org/articles/PMC4151983?pdf=render

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