Peptidoglycan Switches Off the TLR2-Mediated Sperm Recognition and Triggers Sperm Localization in the Bovine Endometrium

Peptidoglycan Switches Off the TLR2-Mediated Sperm Recognition and Triggers Sperm Localization in the Bovine Endometrium

In mammals, the uterine mucosal immune system simultaneously recognizes and reacts to most bacteria as well as allogenic sperm mainly through the Toll-like receptors (TLR)2/4 signaling pathway. Here, we characterized the impact of pathogen-derived TLR2/4 ligands (peptidoglycan (PGN)/lipopolysacchari...

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Bibliographic Details
Main Authors: Ibrahim Fouad Elesh, Mohamed Ali Marey, Mohammed Ali Zinnah, Ihshan Akthar, Tomoko Kawai, Fayrouz Naim, Wael Goda, Abdel Rahman A. Rawash, Motoki Sasaki, Masayuki Shimada, Akio Miyamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
peptidoglycan
sperm
endometrium
toll-like receptor
cluster of differentiation 44
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.619408/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.619408/full

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