The anti-cancer drugs curaxins target spatial genome organization

The anti-cancer drugs curaxins target spatial genome organization

Curaxins are a recently discovered class of anti-cancer agents that disturbs DNA/histone interactions within. Here the authors provide evidence that curaxins affect the spatial genome organization and compromise enhancer-promoter communication necessary for expression of several oncogenes, including...

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Bibliographic Details
Main Authors: Omar L. Kantidze, Artem V. Luzhin, Ekaterina V. Nizovtseva, Alfiya Safina, Maria E. Valieva, Arkadiy K. Golov, Artem K. Velichko, Alexander V. Lyubitelev, Alexey V. Feofanov, Katerina V. Gurova, Vasily M. Studitsky, Sergey V. Razin
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09500-7

Internet

https://doi.org/10.1038/s41467-019-09500-7

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