Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles.

Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles.

Neisseria meningitidis recruits host human complement inhibitors to its surface to down-regulate complement activation and enhance survival in blood. We have investigated whether such complement inhibitor binding occurs after vaccination with native outer membrane vesicles (nOMVs), and limits immuno...

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Bibliographic Details
Main Authors: Helene Daniels-Treffandier, Karlijn de Nie, Leanne Marsay, Christina Dold, Manish Sadarangani, Arturo Reyes-Sandoval, Paul R Langford, David Wyllie, Fergal Hill, Andrew J Pollard, Christine S Rollier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4752311?pdf=render

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http://europepmc.org/articles/PMC4752311?pdf=render

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