Thrombotic Microangiopathy and Acute Kidney Injury Induced After Intravitreal Injection of Vascular Endothelial Growth Factor Inhibitors VEGF Blockade-Related TMA After Intravitreal Use

Thrombotic Microangiopathy and Acute Kidney Injury Induced After Intravitreal Injection of Vascular Endothelial Growth Factor Inhibitors VEGF Blockade-Related TMA After Intravitreal Use

Vascular endothelial growth factor (VEGF) inhibition can cause worsening hypertension, proteinuria, chronic kidney injury, and glomerular disease. Thrombotic microangiopathy (TMA) and other nephrotic disorders have been reported with systemic VEGF blockade. These same agents are given intravitreally...

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Bibliographic Details
Main Authors: Ramy M. Hanna, Ngoc-Tram Tran, Sapna S. Patel, Jean Hou, Kenar D. Jhaveri, Rushang Parikh, Umut Selamet, Lena Ghobry, Olivia Wassef, Marina Barsoum, Vanesa Bijol, Kamyar Kalantar-Zadeh, Alex Pai, Alpesh Amin, Baruch Kupperman, Ira B. Kurtz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Medicine
Subjects:
intravitreal injections
thrombotic microangiopathy
diabetic retinopathy
vascular endothelial growth factor (VEGF)
bevacizumab (avastin)
ranibizumab (Lucentis)
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.579603/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2020.579603/full

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