The oncogene KRAS promotes cancer cell dissemination by stabilizing spheroid formation via the MEK pathway

The oncogene KRAS promotes cancer cell dissemination by stabilizing spheroid formation via the MEK pathway

Abstract Background Peritoneal dissemination is a critical prognostic factor in ovarian cancer. Although stabilized spheroid formation promotes cancer cell peritoneal dissemination in ovarian cancer, the associated oncogenes are unknown. In this study, we assessed the role of the KRAS oncogene in ov...

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Main Authors: Juri Ogishima, Ayumi Taguchi, Akira Kawata, Kei Kawana, Mitsuyo Yoshida, Yuki Yoshimatsu, Masakazu Sato, Hiroe Nakamura, Yoshiko Kawata, Akira Nishijima, Asaha Fujimoto, Kensuke Tomio, Katsuyuki Adachi, Takeshi Nagamatsu, Katsutoshi Oda, Tohru Kiyono, Yutaka Osuga, Tomoyuki Fujii
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
Spheroid formation
KRAS
MEK pathway
MEK inhibitor
Trametinib
Online Access:http://link.springer.com/article/10.1186/s12885-018-4922-4

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http://link.springer.com/article/10.1186/s12885-018-4922-4

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