IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells

IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells

Abstract Background Recently, immunotherapy with anti-PD-1 antibodies has shown clinical benefit in recurrent Small Cell Lung Cancer (SCLC). Since anti-PD-1 re-activates anti-tumor Cytotoxic T Lymphocyte (CTL) responses, it is crucial to understand the mechanisms regulating HLA class I, and PD-L1 ex...

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Bibliographic Details
Main Authors: Grazia Carbotti, Amin Reza Nikpoor, Paola Vacca, Rosaria Gangemi, Chiara Giordano, Francesco Campelli, Silvano Ferrini, Marina Fabbi
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
IL-27
IL-6
Small Cell Lung Cancer
HLA class I
PD-L1
STAT1/3
Online Access:http://link.springer.com/article/10.1186/s13046-017-0608-z

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http://link.springer.com/article/10.1186/s13046-017-0608-z

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