Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization

Large-scale in vitro assays may reduce the number of toxicological tests carried out in animals. Here, Huang et al. report a large dataset containing results of in vitrotests of approximately 10,000 chemicals, and use these data to create models that can potentially predict toxicity in humans.

Bibliographic Details
Main Authors: Ruili Huang, Menghang Xia, Srilatha Sakamuru, Jinghua Zhao, Sampada A. Shahane, Matias Attene-Ramos, Tongan Zhao, Christopher P. Austin, Anton Simeonov
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10425