Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

Multiple sclerosis (MS) is a demyelinating autoimmune disease in which innate and adaptive immune cells infiltrate the central nervous system (CNS) and damage the myelin sheaths surrounding the axons. Upon activation, infiltrated macrophages, CNS-resident microglia, and astrocytes switch their metab...

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Bibliographic Details
Main Authors: Suzan Wetzels, Tim Vanmierlo, Jean L. J. M. Scheijen, Jack van Horssen, Sandra Amor, Veerle Somers, Casper G. Schalkwijk, Jerome J. A. Hendriks, Kristiaan Wouters
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
neuroinflammation
α-dicarbonyl
advanced glycation endproducts
astrocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00855/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00855/full

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