Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity

Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity

Summary How the direction of axon guidance is determined is not understood. In Caenorhabditis elegans the UNC-40 (DCC) receptor mediates a response to the UNC-6 (netrin) guidance cue that directs HSN axon development. UNC-40 becomes asymmetrically localized within the HSN neuron to the site of axon...

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Bibliographic Details
Main Authors: Gauri Kulkarni, Zhennan Xu, Ahmed M. Mohamed, Haichang Li, Xia Tang, Gerard Limerick, William G. Wadsworth
Format: Article
Language:English
Published: The Company of Biologists 2013-10-01
Series:Biology Open
Subjects:
Caenorhabditis elegans
DCC receptor
Netrin
Stochastic Process
UNC-6
Axon guidance
Wnt signaling
Neurons
Online Access:http://bio.biologists.org/content/2/12/1300

Internet

http://bio.biologists.org/content/2/12/1300

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