ZPR1-Dependent Neurodegeneration Is Mediated by the JNK Signaling Pathway

The zinc finger protein ZPR1 deficiency causes neurodegeneration and results in a mild spinal muscular atrophy (SMA)-like disease in mice with reduced Zpr1 gene dosage. Mutation of the survival motor neuron 1 ( SMN1 ) gene causes SMA. Spinal muscular atrophy is characterized by the degeneration of t...

Full description

Bibliographic Details
Main Authors: Xiaoting Jiang, Annapoorna Kannan, Laxman Gangwani
Format: Article
Language:English
Published: SAGE Publishing 2019-08-01
Series:Journal of Experimental Neuroscience
Online Access:https://doi.org/10.1177/1179069519867915