Novel Broccoli Sulforaphane-Based Analogues Inhibit the Progression of Pancreatic Cancer without Side Effects

Novel Broccoli Sulforaphane-Based Analogues Inhibit the Progression of Pancreatic Cancer without Side Effects

The naturally occurring isothiocyanate sulforaphane, found in <i>Brassicaceae</i> vegetables, is promising in cancer treatment, e.g., by the normalization of enhanced levels of NF-κB-signaling in tumor stem cells. We chemically synthesized seven sulforaphane analogues by substitution of...

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Bibliographic Details
Main Authors: Christina Georgikou, Laura Buglioni, Maximilian Bremerich, Nico Roubicek, Libo Yin, Wolfgang Gross, Carsten Sticht, Carsten Bolm, Ingrid Herr
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Biomolecules
Subjects:
bioactive agents
drug development
microRNA signaling
pancreatic cancer
NCI-60
sulforaphane
Online Access:https://www.mdpi.com/2218-273X/10/5/769

Internet

https://www.mdpi.com/2218-273X/10/5/769

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