The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection

The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection

TGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in a two-hit mouse model of murine γ-herpesvirus 68 (MHV-68) in...

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Bibliographic Details
Main Authors: Natalia Smoktunowicz, Robert E. Alexander, Linda Franklin, Andrew E. Williams, Beverley Holman, Paul F. Mercer, Gabor Jarai, Chris J. Scotton, Rachel C. Chambers
Format: Article
Language:English
Published: The Company of Biologists 2015-09-01
Series:Disease Models & Mechanisms
Subjects:
Pulmonary fibrosis
Viral infection
Collagen
TGFβ
µCT
Online Access:http://dmm.biologists.org/content/8/9/1129

Internet

http://dmm.biologists.org/content/8/9/1129

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