Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function.

Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function.

Varicella zoster virus (VZV) is a lymphotropic alpha-herpesvirinae subfamily member that produces varicella on primary infection and causes zoster, vascular disease and vision loss upon reactivation from latency. VZV-infected peripheral blood mononuclear cells (PBMCs) disseminate virus to distal org...

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Bibliographic Details
Main Authors: Dallas Jones, Christina N Como, Lichen Jing, Anna Blackmon, Charles Preston Neff, Owen Krueger, Andrew N Bubak, Brent E Palmer, David M Koelle, Maria A Nagel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007650

Internet

https://doi.org/10.1371/journal.ppat.1007650

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