Interleukin-1 and Systemic Sclerosis: Getting to the Heart of Cardiac Involvement

Interleukin-1 and Systemic Sclerosis: Getting to the Heart of Cardiac Involvement

Systemic sclerosis (SSc) is rare, severe connective tissue disease characterized by endothelial and vascular damage, immune activation, and resulting in inflammation and fibrosis of skin and internal organs, including the heart. SSc is associated with high morbidity and mortality. Cardiac involvemen...

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Bibliographic Details
Main Authors: Giacomo De Luca, Giulio Cavalli, Corrado Campochiaro, Cosimo Bruni, Alessandro Tomelleri, Lorenzo Dagna, Marco Matucci-Cerinic
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
systemic sclerosis (scleroderma)
heart inflammation
interleukin-1
inflammasome
cellular metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.653950/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.653950/full

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