The amino acid selected for generating mutant TbpB antigens defective in binding transferrin can compromise the in vivo protective capacity

The amino acid selected for generating mutant TbpB antigens defective in binding transferrin can compromise the in vivo protective capacity

Abstract Haemophilus parasuis is the causative agent of the Glässer’s disease (GD), one of the most important bacterial diseases that affect young pigs worldwide. GD prevention based on vaccination is a major concern due to the limited cross-protection conferred by the inactivated whole cell vaccine...

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Main Authors: João Antônio Guizzo, Somshukla Chaudhuri, Simone Ramos Prigol, Rong-hua Yu, Cláudia Cerutti Dazzi, Natalia Balbinott, Gabriela Paraboni Frandoloso, Luiz Carlos Kreutz, Rafael Frandoloso, Anthony Bernard Schryvers
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25685-1

Internet

https://doi.org/10.1038/s41598-018-25685-1

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