Establishment of a 3D In Vitro Model to Accelerate the Development of Human Therapies against Corneal Diabetes.

To establish an in vitro model that would mirror the in vivo corneal stromal environment in diabetes (DM) patients.Human corneal fibroblasts from Healthy (HCFs), Type 1DM (T1DM) and Type 2DM (T2DM) donors were isolated and cultured for 4 weeks with Vitamin C stimulation in order to allow for extrace...

Full description

Bibliographic Details
Main Authors: Shrestha Priyadarsini, Akhee Sarker-Nag, Tyler G Rowsey, Jian-Xing Ma, Dimitrios Karamichos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5179241?pdf=render