Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss

Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss

Abstract Background Bone mass loss in aging is linked with imbalanced lineage differentiation of bone marrow mesenchymal stem cells (BMMSCs). Recent studies have proved that histone deacetylases (HDACs) are regarded as key regulators of bone remodeling. However, HDACs involve in regulating BMMSC bio...

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Bibliographic Details
Main Authors: Liqiang Zhang, Meng Qi, Ji Chen, Jiangdong Zhao, Liya Li, Jiachen Hu, Yan Jin, Wenjia Liu
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Stem Cell Research & Therapy
Subjects:
Bone mass loss
HDACs
BMMSCs
Autophagy
Lineage differentiation
Online Access:http://link.springer.com/article/10.1186/s13287-020-01785-6

Internet

http://link.springer.com/article/10.1186/s13287-020-01785-6

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