Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments

<p>Abstract</p> <p>Background</p> <p>While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor and a similar structure; pairwise sequence alignments often fail t...

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Bibliographic Details
Main Authors: Bass Ellen J, Smoot Michael E, Sierk Michael L, Pearson William R
Format: Article
Language:English
Published: BMC 2010-03-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/11/146