The Identification of Small Molecule Inhibitors That Reduce Invasion and Metastasis of Aggressive Cancers

The Identification of Small Molecule Inhibitors That Reduce Invasion and Metastasis of Aggressive Cancers

Transformed epithelial cells can activate programs of epithelial plasticity and switch from a sessile, epithelial phenotype to a motile, mesenchymal phenotype. This process is linked to the acquisition of an invasive phenotype and the formation of distant metastases. The development of compounds tha...

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Bibliographic Details
Main Authors: Arjanneke F. van de Merbel, Onno van Hooij, Geertje van der Horst, Cindy C. M. van Rijt-van de Westerlo, Maaike H. van der Mark, Henry Cheung, Jan Kroon, Gerald W. Verhaegh, Johan Tijhuis, Antoine Wellink, Peter Maas, Henk Viëtor, Jack A. Schalken, Gabri van der Pluijm
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
small molecule inhibitors
prostate cancer
breast cancer
bladder cancer
metastasis
invasiveness
Online Access:https://www.mdpi.com/1422-0067/22/4/1688

Internet

https://www.mdpi.com/1422-0067/22/4/1688

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