Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury

Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury

BackgroundAcute kidney injury (AKI) is a severe complication of sepsis; however, no effective drugs have been found. Activation of the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome is a major pathogenic mechanism of AKI induced by lipopolysaccharide (LPS). Autophagy, a proce...

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Bibliographic Details
Main Authors: Tianyuan Yang, Xiujing Feng, Yuan Zhao, Haiyang Zhang, Hailin Cui, Mian Wei, Haotian Yang, Honggang Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
acute kidney injury
dexmedetomidine
autophagy
NLRP3 inflammasome
α2-AR/AMPK/mTOR pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00790/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00790/full

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