Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

<p>Abstract</p> <p>Background</p> <p>In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate telomere shortening and...

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Bibliographic Details
Main Authors: Batchu Ramesh B, Koley Hemanta, Shammas Masood A, Bertheau Robert C, Protopopov Alexei, Munshi Nikhil C, Goyal Raj K
Format: Article
Language:English
Published: BMC 2005-07-01
Series:Molecular Cancer
Subjects:
SiRNA, Telomerase, Telomere
Barrett's esophageal adenocarcinoma
Senescence, Apoptosis, Cancer treatment
Cancer prevention, P73, P63
Online Access:http://www.molecular-cancer.com/content/4/1/24

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http://www.molecular-cancer.com/content/4/1/24

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