Poloxamer 188 Attenuates Ischemia-Reperfusion-Induced Lung Injury by Maintaining Cell Membrane Integrity and Inhibiting Multiple Signaling Pathways

Poloxamer 188 Attenuates Ischemia-Reperfusion-Induced Lung Injury by Maintaining Cell Membrane Integrity and Inhibiting Multiple Signaling Pathways

Background: Poloxamer 188 (P188) possesses anti-inflammatory properties and can help to maintain plasma membrane function. P188 has been reported to exert beneficial effects in the treatment of various disorders. However, the effects of P188 in ischemia/reperfusion (IR)-induced acute lung injury hav...

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Bibliographic Details
Main Authors: Shih-En Tang, Wen-I Liao, Hsin-Ping Pao, Chin-Wang Hsu, Shu-Yu Wu, Kun-Lun Huang, Shi-Jye Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
acute lung injury
ischemia-reperfusion
poloxamer 188
hypoxia/reoxygenation
membrane integrity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.650573/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.650573/full

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