Activation of the Interferon Pathway is Dependent upon Autoantibodies to RNA-binding Proteins in African-American SLE Patients, but not in European-American SLE Patients

Activation of the Interferon Pathway is Dependent upon Autoantibodies to RNA-binding Proteins in African-American SLE Patients, but not in European-American SLE Patients

Background: In systemic lupus erythematosus (SLE), antibodies directed at RNA-binding proteins (anti-RBP) are associated with high serum type I interferon (IFN), which plays an important role in SLE pathogenesis. African-Americans (AA) are more likely to develop SLE, and SLE is also more severe in...

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Bibliographic Details
Main Authors: Kichul eKo, Yelena eKoldobskaya, Elizabeth eRosenzweig, Timothy B. Niewold
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Immunology
Subjects:
Autoantibodies
Interferon-gamma
interferon alpha
systemic lupus erythematosus
ancestral background
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00309/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00309/full

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