Dengue virus activates membrane TRAIL relocalization and IFN-α production by human plasmacytoid dendritic cells in vitro and in vivo.

Dengue virus activates membrane TRAIL relocalization and IFN-α production by human plasmacytoid dendritic cells in vitro and in vivo.

BACKGROUND: Dengue displays a broad spectrum of clinical manifestations that may vary from asymptomatic to severe and even fatal features. Plasma leakage/hemorrhages can be caused by a cytokine storm induced by monocytes and dendritic cells during dengue virus (DENV) replication. Plasmacytoid dendri...

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Main Authors: Mariana Gandini, Christophe Gras, Elzinandes Leal Azeredo, Luzia Maria de Oliveira Pinto, Nikaïa Smith, Philippe Despres, Rivaldo Venâncio da Cunha, Luiz José de Souza, Claire Fernandes Kubelka, Jean-Philippe Herbeuval
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3675005?pdf=render

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http://europepmc.org/articles/PMC3675005?pdf=render

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