Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells.

Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells.

Human embryonic stem cells (hESCs) are primed for rapid apoptosis following mild forms of genotoxic stress. A natural form of such cellular stress occurs in response to recombinant adeno-associated virus (rAAV) single-strand DNA genomes, which exploit the host DNA damage response for replication and...

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Bibliographic Details
Main Authors: Matthew L Hirsch, B Matthew Fagan, Raluca Dumitru, Jacquelyn J Bower, Swati Yadav, Matthew H Porteus, Larysa H Pevny, R Jude Samulski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3219675?pdf=render

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http://europepmc.org/articles/PMC3219675?pdf=render

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