Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Abstract Background Due to its neurotoxic properties, oligomeric alpha-synuclein (α-syn) has been suggested as an attractive target for passive immunization against Parkinson’s disease (PD). In mouse models of PD, antibody treatment has been shown to lower the levels of pathogenic α-syn species, inc...

Full description

Bibliographic Details
Main Authors: Gabriel Gustafsson, Veronica Lindström, Jinar Rostami, Eva Nordström, Lars Lannfelt, Joakim Bergström, Martin Ingelsson, Anna Erlandsson
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neuroinflammation
Subjects:
α-synuclein oligomers
Astrocytes
Antibodies
Mitochondria
Lysosomal degradation
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s12974-017-1018-z

Internet

http://link.springer.com/article/10.1186/s12974-017-1018-z

Similar Items