Notch activation promotes endothelial quiescence by repressing MYC expression via miR-218

Notch activation promotes endothelial quiescence by repressing MYC expression via miR-218

After angiogenesis-activated embryonic and early postnatal vascularization, endothelial cells (ECs) in most tissues enter a quiescent state necessary for proper tissue perfusion and EC functions. Notch signaling is essential for maintaining EC quiescence, but the mechanisms of action remain elusive....

Full description

Bibliographic Details
Main Authors: Jia-Xing Sun, Guo-Rui Dou, Zi-Yan Yang, Liang Liang, Juan-Li Duan, Bai Ruan, Man-Hong Li, Tian-Fang Chang, Xin-Yuan Xu, Juan-Juan Chen, Yu-Sheng Wang, Xian-Chun Yan, Hua Han
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
miR-218
endothelial cells
Notch
MYC
angiogenesis
quiescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001918

Internet

http://www.sciencedirect.com/science/article/pii/S2162253121001918

Similar Items