Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress

Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress

Incomplete and low-fidelity genome duplication contribute to genomic instability and cancer development. Difficult-to-Replicate Sequences, or DiToRS, are natural impediments in the genome that require specialized DNA polymerases and repair pathways to complete and maintain faithful DNA synthesis. Di...

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Bibliographic Details
Main Authors: Wei-Chung Tsao, Kristin A. Eckert
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
Difficult-to-Replicate Sequences
replication stress
non-B DNA
Polymerase eta
Polymerase kappa
genome instability
common fragile sites
Microsatellites
Online Access:http://www.mdpi.com/1422-0067/19/10/3255

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http://www.mdpi.com/1422-0067/19/10/3255

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