Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State

Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State

Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral genomes and disease etiology, many fusion...

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Bibliographic Details
Main Authors: Anna Lappala, Wataru Nishima, Jacob Miner, Paul Fenimore, Will Fischer, Peter Hraber, Ming Zhang, Benjamin McMahon, Chang-Shung Tung
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Biomolecules
Subjects:
EBOV GP
ZIKV E
pre-fusion-to-fusion transition
antibody binding
Online Access:http://www.mdpi.com/2218-273X/8/2/25

Internet

http://www.mdpi.com/2218-273X/8/2/25

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