Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB signaling pathway without inflammation

Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB signaling pathway without inflammation

Peptide vaccine targeting tumor-specific antigens is a promising cancer treatment regimen. However, peptide vaccines are commonly low-immunogenic, leading to suboptimal antitumor T-cell responses. Current peptide vaccination approaches are challenged by the variability of peptide physicochemical cha...

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Bibliographic Details
Main Authors: Qi Su, Huijuan Song, Pingsheng Huang, Chuangnian Zhang, Jing Yang, Deling Kong, Weiwei Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-11-01
Series:Bioactive Materials
Subjects:
Cancer immunotherapy
Vaccination
Peptide
Co-assembly
Self-adjuvanting
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21001523

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http://www.sciencedirect.com/science/article/pii/S2452199X21001523

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