NFκB Inhibition Mitigates Serum Amyloid A-Induced Pro-Atherogenic Responses in Endothelial Cells and Leukocyte Adhesion and Adverse Changes to Endothelium Function in Isolated Aorta

NFκB Inhibition Mitigates Serum Amyloid A-Induced Pro-Atherogenic Responses in Endothelial Cells and Leukocyte Adhesion and Adverse Changes to Endothelium Function in Isolated Aorta

The acute phase protein serum amyloid A (SAA) is associated with endothelial dysfunction and early-stage atherogenesis. Stimulation of vascular cells with SAA increases gene expression of pro-inflammation cytokines and tissue factor (TF). Activation of the transcription factor, nuclear factor kappa-...

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Bibliographic Details
Main Authors: Abigail Vallejo, Belal Chami, Joanne M. Dennis, Martin Simone, Gulfam Ahmad, Adrian I. Abdo, Arpeeta Sharma, Waled A. Shihata, Nathan Martin, Jaye P. F. Chin-Dusting, Judy B. de Haan, Paul K. Witting
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
nuclear
transcription
endothelium
atherosclerosis
serum amyloid A
aorta
Online Access:http://www.mdpi.com/1422-0067/20/1/105

Internet

http://www.mdpi.com/1422-0067/20/1/105

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