Tissue specific microenvironments: a key tool for tissue engineering and regenerative medicine

Abstract The accumulated evidence points to the microenvironment as the primary mediator of cellular fate determination. Comprised of parenchymal cells, stromal cells, structural extracellular matrix proteins, and signaling molecules, the microenvironment is a complex and synergistic edifice that va...

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Bibliographic Details
Main Authors: Patrick C. Sachs, Peter A. Mollica, Robert D. Bruno
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Biological Engineering
Online Access:http://link.springer.com/article/10.1186/s13036-017-0077-0