Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[<i>b</i>]furans against Multiple Targets Linked to Type 2 Diabetes

Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[<i>b</i>]furans against Multiple Targets Linked to Type 2 Diabetes

The 5-acetyl-2-aryl-6-hydroxybenzo[<i>b</i>]furans <b>2a</b>&#8722;<b>h</b> have been evaluated through in vitro enzymatic assay against targets which are linked to type 2 diabetes (T2D), namely, &#945;-glucosidase, protein tyrosine phosphatase 1B (PTP1B)...

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Bibliographic Details
Main Authors: Malose J. Mphahlele, Yee Siew Choong, Marole M. Maluleka, Samantha Gildenhuys
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
5-acetyl-2-aryl-6-hydroxybenzo[<i>b</i>]furans
α-glucosidase
protein tyrosine phosphatase 1b
β-secretase
antioxidant activity
cyclooxygenase-2
molecular docking
Online Access:https://www.mdpi.com/2218-273X/10/3/418

Internet

https://www.mdpi.com/2218-273X/10/3/418

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