Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes.

Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes.

Establishment of stable HIV-1 infection requires the efficient integration of the retroviral genome into the host DNA. The molecular mechanism underlying the control of this process by the chromatin structure has not yet been elucidated. We show here that stably associated nucleosomes strongly inhib...

Full description

Bibliographic Details
Main Authors: Paul Lesbats, Yair Botbol, Guillaume Chevereau, Cédric Vaillant, Christina Calmels, Alain Arneodo, Marie-Line Andreola, Marc Lavigne, Vincent Parissi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3037357?pdf=render

Internet

http://europepmc.org/articles/PMC3037357?pdf=render

Similar Items