Inhibiting MARSs reduces hyperhomocysteinemia‐associated neural tube and congenital heart defects

Inhibiting MARSs reduces hyperhomocysteinemia‐associated neural tube and congenital heart defects

Abstract Hyperhomocysteinemia is a common metabolic disorder that imposes major adverse health consequences. Reducing homocysteine levels, however, is not always effective against hyperhomocysteinemia‐associated pathologies. Herein, we report the potential roles of methionyl‐tRNA synthetase (MARS)‐g...

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Bibliographic Details
Main Authors: Xinyu Mei, Dashi Qi, Ting Zhang, Ying Zhao, Li Jin, Junli Hou, Jianhua Wang, Yan Lin, Yu Xue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, Jianhong Ye, Richard H Finnell, Hexige Saiyin, Hongyan Wang, Jianyuan Zhao, Shimin Zhao, Wei Xu
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:EMBO Molecular Medicine
Subjects:
acetyl homocysteine thioether
methionyl‐tRNA synthetase
neural tube defects
N‐homocysteinylation
reactive oxygen species
Online Access:https://doi.org/10.15252/emmm.201809469

Internet

https://doi.org/10.15252/emmm.201809469

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