Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice

Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is predominantly expressed in liver and regulates cholesterol metabolism by down regulating liver LDL receptor (LDLR) proteins. Here we report transgenic overexpression of human PCSK9 in kidney increased plasma levels of PCSK9 and subsequently le...

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Bibliographic Details
Main Authors: Yi Luo, Laurie Warren, Donghui Xia, Heather Jensen, Thomas Sand, Stephen Petras, Wenning Qin, Kenneth S. Miller, Julie Hawkins
Format: Article
Language:English
Published: Elsevier 2009-08-01
Series:Journal of Lipid Research
Subjects:
HFHC
low density lipoprotein receptor
proprotein convertase subtilisin/kexin type 9
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520307598

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http://www.sciencedirect.com/science/article/pii/S0022227520307598

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