Functional Inactivation of <i>Drosophila</i> <i>GCK</i> Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2

Functional Inactivation of <i>Drosophila</i> <i>GCK</i> Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2

Maturity-onset diabetes of the young (MODY) type 2 is caused by heterozygous inactivating mutations in the gene encoding glucokinase (GCK), a pivotal enzyme for glucose homeostasis. In the pancreas GCK regulates insulin secretion, while in the liver it promotes glucose utilization and storage. We sh...

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Bibliographic Details
Main Authors: Elisa Mascolo, Francesco Liguori, Lorenzo Stufera Mecarelli, Noemi Amoroso, Chiara Merigliano, Susanna Amadio, Cinzia Volonté, Roberto Contestabile, Angela Tramonti, Fiammetta Vernì
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
MODY-2
<i>Drosophila melanogaster</i>
glucokinase
chromosome aberrations
vitamin B6
Online Access:https://www.mdpi.com/1422-0067/22/2/918

Internet

https://www.mdpi.com/1422-0067/22/2/918

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