Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15.

Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15.

Obese states characterized by chronic inflammation are closely linked to the development of metabolic dysfunction. We identified adipolin/CTRP12 as an insulin-sensitizing and anti-inflammatory adipokine. Although obese conditions down-regulate adipolin expression, its molecular mechanism is largely...

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Bibliographic Details
Main Authors: Takashi Enomoto, Koji Ohashi, Rei Shibata, Takahiro Kambara, Yusuke Uemura, Daisuke Yuasa, Yoshiyuki Kataoka, Megumi Miyabe, Kazuhiro Matsuo, Yusuke Joki, Satoko Hayakawa, Mizuho Hiramatsu-Ito, Masanori Ito, Toyoaki Murohara, Noriyuki Ouchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3865152?pdf=render

Internet

http://europepmc.org/articles/PMC3865152?pdf=render

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