Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Abstract Pyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a newly identified mediator of pyroptosis via the cleavage of caspase-3 generating pyroptotic GSDME-N. Here, we...

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Bibliographic Details
Main Authors: Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03431-2

Internet

https://doi.org/10.1038/s41419-021-03431-2

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