Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury

Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury

The survival of microglia depends on the colony-stimulating factor-1 receptor (CSF1R) signaling pathway under physiological conditions. Ki20227 is a highly selective CSF1R inhibitor that has been shown to change the morphology of microglia. However, the effects of Ki20227 on the progression of ische...

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Bibliographic Details
Main Authors: Cheng Jiang, Ze-Ning Wang, Yu-Chen Kang, Yi Chen, Wei-Xin Lu, Hai-Jun Ren, Bo-Ru Hou
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
apoptosis; colony-stimulating factor-1 receptor; inflammatory response; ischemia/reperfusion; ki20227; microglia; oxidative stress; transient middle cerebral artery occlusion
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=137;epage=143;aulast=Jiang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=137;epage=143;aulast=Jiang

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